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KMID : 1134819970260020242
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 2 p.242 ~ p.247
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Isolation of Flavone Glycoside from Circium japonicum var ussuriense and Biological Activity on the Cardiovascular System
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Lim Sang-Sun
Lee Jong-Ho
Park Jong-Cheol
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Abstract
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A flavone glycoside was separated from the aerial part of Circium japonicum var ussuriense Kitamura and the effect on cardiovascular system was investigated. The cadiovascular contractility of this compound was observed in the artria and aortae from normal rats. It increased the spontancous beat in right atria and the contractile force in left atria, and caused the contraction of thoracic aortae. For the blood pressure, it had ascending effect. The effective component, which acted on stimulation and contraction in the artria and aortae of rats was fractionated with n-BuOH, separated and identified by column chromatography, UV, IR, ¹H-NMR and ¹³C-NMR. The chemical structure for this component was determined to be hispidulin-7-α-rhamnopyranosyl(1→2)-β-D-glucopyranoside.
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KEYWORD
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Circium japonicum var ussuriense, cardiovascular response, contractility, blood pressure, flavone glycoside
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